Binimetinib

Quick meaning: Binimetinib is a noun meaning (pharmacology) A drug with the molecular formula C₁₇H₁₅BrF₂N₄O₃ that inhibits mitogen-activated protein kinase kinase (MEK), and is approved for use in combination with encorafenib to treat certain melanomas.

Meaning

(pharmacology) A drug with the molecular formula C₁₇H₁₅BrF₂N₄O₃ that inhibits mitogen-activated protein kinase kinase (MEK), and is approved for use in combination with encorafenib to treat certain melanomas.

Example Sentences

Binimetinib improved progression-free survival compared with dacarbazine and was tolerable. Binimetinib might represent a new treatment option for patients with NRAS-mutant melanoma after failure of immunotherapy.

Under development are binimetinib, a MEK inhibitor being studied in patients with NRAS-mutant melanoma, and encorafinib, a BRAF inhibitor being used in combination with binimetinib for patients with BRAF-mutant melanoma.

The initial report of the phase I/II combination trial of encorafenib and binimetinib reported on 9 BRAF inhibitor naive and 14 BRAF inhibitor pretreated patients with metastatic BRAF mutant melanoma across a range of doses.

Special Considerations [...] 7. Monitor patients for an increased risk of new primary cancers, both cutaneous and non-cutaneous, while on therapy and for up to 6 months following the last dose of binimetinib. [...] 10. Baseline and periodic CPK levels while on therapy, as rhabdomyolysis has been observed with binimetinib therapy.

Related Words

Related dictionary entries include cobimetinib, trametinib, bafetinib, imatinib, refametinib, masitinib.

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