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/ˈkəʊ.diːn/ · noun
(pharmacology) An addictive alkaloid narcotic derived from opium and used as a hypnotic, analgesic and antitussive; often mixed with aspirin etc..
Use codeine when its meaning, tone and grammar fit the full sentence. A synonym is not always a direct replacement.
Codeine means (pharmacology) An addictive alkaloid narcotic derived from opium and used as a hypnotic, analgesic and antitussive; often mixed with aspirin etc..
The closest synonym depends on the sentence and intended sense.
The opposite depends on the specific sense.
Use codeine where its definition matches the intended context.
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