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Pronunciation varies by accent · noun
Disproportionate size or growth of the airways in comparison with the lung parenchyma..
In other words, parenchyma could be to some extent molded according to the environment (airways and chest) in which it is forming, whereas this seems relatively less likely for the tracheobronchial tree itself. At any rate within normal individuals there seems to be opportunity for physiological variation in the geometry of the tracheobronchial tree and parenchyma due to different patterns of embryonic growth. We searched for a term to describe this type of growth pattern and were not able to find one. We therefore suggest the word "dys-anaptic" (from the Greek dys = unequal, and anaptixy = growth) to indicate the concept of a growth pattern which may, within limits, occur disproportionately between constituent parts of an organ while allowing normal physiological function of the whole.
The concept of the disproportionate growth between lung size and airway caliber was termed "dysanaptic growth" by Green and colleagues in 1974 […] This is all physiologically interesting; however, is it clinically important? In this edition of the Journal, Forno and colleagues (pp. 314–323) present a comprehensive study looking at the question of whether airway dysanapsis is associated with asthma morbidity in obese children.
Question: Is dysanapsis, a mismatch of airway tree caliber to lung size, associated with subsequent risk of chronic obstructive pulmonary disease (COPD)? […] Meaning: Among older adults, dysanapsis appears to be a risk factor associated with COPD. […] Dysanapsis refers to a mismatch of airway tree caliber to lung size and was initially inferred from variation in spirometry among healthy adults.
Use dysanapsis when its meaning, tone and grammar fit the full sentence. A synonym is not always a direct replacement.
Dysanapsis means Disproportionate size or growth of the airways in comparison with the lung parenchyma..
The closest synonym depends on the sentence and intended sense.
The opposite depends on the specific sense.
In other words, parenchyma could be to some extent molded according to the environment (airways and chest) in which it is forming, whereas this seems relatively less likely for the tracheobronchial tree itself. At any rate within normal individuals there seems to be opportunity for physiological variation in the geometry of the tracheobronchial tree and parenchyma due to different patterns of embryonic growth. We searched for a term to describe this type of growth pattern and were not able to find one. We therefore suggest the word "dys-anaptic" (from the Greek dys = unequal, and anaptixy = growth) to indicate the concept of a growth pattern which may, within limits, occur disproportionately between constituent parts of an organ while allowing normal physiological function of the whole.
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