Ruxolitinib
Definition, Meaning & Examples
Part of speech noun
Quick meaning: Ruxolitinib is a noun meaning (pharmacology) A medication belonging to the class of Janus kinase inhibitors, used for the treatment of several diseases including myelofibrosis and polycythemia vera.
Meaning
(pharmacology) A medication belonging to the class of Janus kinase inhibitors, used for the treatment of several diseases including myelofibrosis and polycythemia vera.
Example Sentences
For example, Gallipoli et al. reported that combination of nilotinib with ruxolitinib could induce apoptosis in chronic myeloid leukemia (CML) stem cells through inhibiting JAK-2/STAT-5 signaling pathway.
The first jakinib to enter clinical trials, initially for renal transplantation, was tofacitinib, which inhibits JAK1/JAK2/JAK3; however, ruxolitinib, a JAK1/JAK2 inhibitor, was the first agent to receive approval, as a treatment for myeloproliferative neoplasms that often exhibit gain-of-function JAK2 mutations.
Related Words
Related dictionary entries include ritlecitinib, fedratinib, momelotinib, quizartinib, pacritinib, brepocitinib.
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Sources & Attribution
FreeDictionaryAPI.com / Wiktionary · Original source · CC BY-SA 4.0
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