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Pronunciation varies by accent · noun
(pharmacology) A medication belonging to the class of Janus kinase inhibitors, used for the treatment of several diseases including myelofibrosis and polycythemia vera..
For example, Gallipoli et al. reported that combination of nilotinib with ruxolitinib could induce apoptosis in chronic myeloid leukemia (CML) stem cells through inhibiting JAK-2/STAT-5 signaling pathway.
The first jakinib to enter clinical trials, initially for renal transplantation, was tofacitinib, which inhibits JAK1/JAK2/JAK3; however, ruxolitinib, a JAK1/JAK2 inhibitor, was the first agent to receive approval, as a treatment for myeloproliferative neoplasms that often exhibit gain-of-function JAK2 mutations.
Use ruxolitinib when its meaning, tone and grammar fit the full sentence. A synonym is not always a direct replacement.
Ruxolitinib means (pharmacology) A medication belonging to the class of Janus kinase inhibitors, used for the treatment of several diseases including myelofibrosis and polycythemia vera..
The closest synonym depends on the sentence and intended sense.
The opposite depends on the specific sense.
For example, Gallipoli et al. reported that combination of nilotinib with ruxolitinib could induce apoptosis in chronic myeloid leukemia (CML) stem cells through inhibiting JAK-2/STAT-5 signaling pathway.
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