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An enzyme of macromolecular size due to unusual biopolymerization or immune complexing, such as when a normal enzyme is protein-bound, typically by immunoglobulins (antibodies); macroenzymes by themselves are not always pathophysiologic or pathogenic, but their occurrence is increased in certain diseases (their formation is encouraged by some pathogenetic processes).
Related-word data is supplemented by the Datamuse API. Datamuse results are suggestions, not automatic replacements.