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Pronunciation varies by accent · noun
(genetics, pathology) A multiple of chromosomal rearrangements that is associated with some cancers..
But for 2—3% of cancers, particularly bone cancer (up to 25%), recent evidence suggests that a single event of chromothripsis involving one or a few chromosomes leads to multiple gene rearrangements (in some cases tens to hundreds) that can disrupt tumor suppressor genes and/or produce oncogenic fusion genes.
Another new phenomenon described by Stephens et al.[86] is called “chromothripsis”. Chromothripsis describes a massive genomic rearrangement in one or more chromosomes in a single catastrophic event during the cells' history,
Some of the characteristics of chromothripsis are oscillating copy number changes, clustering of breakpoints, localized rearrangements involving one or a part of a chromosome, and complex rearrangements.
Use chromothripsis when its meaning, tone and grammar fit the full sentence. A synonym is not always a direct replacement.
Chromothripsis means (genetics, pathology) A multiple of chromosomal rearrangements that is associated with some cancers..
The closest synonym depends on the sentence and intended sense.
The opposite depends on the specific sense.
But for 2—3% of cancers, particularly bone cancer (up to 25%), recent evidence suggests that a single event of chromothripsis involving one or a few chromosomes leads to multiple gene rearrangements (in some cases tens to hundreds) that can disrupt tumor suppressor genes and/or produce oncogenic fusion genes.
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