Chromothripsis

Quick meaning: Chromothripsis is a noun meaning (genetics, pathology) A multiple of chromosomal rearrangements that is associated with some cancers.

Meaning

(genetics, pathology) A multiple of chromosomal rearrangements that is associated with some cancers.

Example Sentences

Some of the characteristics of chromothripsis are oscillating copy number changes, clustering of breakpoints, localized rearrangements involving one or a part of a chromosome, and complex rearrangements.

Another new phenomenon described by Stephens et al.[86] is called “chromothripsis”. Chromothripsis describes a massive genomic rearrangement in one or more chromosomes in a single catastrophic event during the cells' history,

But for 2—3% of cancers, particularly bone cancer (up to 25%), recent evidence suggests that a single event of chromothripsis involving one or a few chromosomes leads to multiple gene rearrangements (in some cases tens to hundreds) that can disrupt tumor suppressor genes and/or produce oncogenic fusion genes.

Related Words

Related dictionary entries include chromoplexy, trisomy, multimutation, chromosomatisation, polymitosis, replichore.

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