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Pronunciation varies by accent · noun
(organic chemistry) A naturally occurring ultrapotent capsaicin analogue (having in its pure form a Scoville heat unit measure of 16,000,000,000) that activates the receptor TRPV1 (aka vanilloid receptor 1 or the capsaicin receptor) in a subpopulation of primary afferent sensory neurons involved in nociception..
1992, Arpad Szallasi, Peter M. Blumberg, 27: Resiniferatoxin, P. Michael Conn (editor), Neurotoxins, Harcourt Brace Jovanovich (Academic Press), page 368, An exciting recent advance in the vanilloid field has been our discovery that resiniferatoxin (RTX), a naturally occurring diterpene combining structural features of the phorbol ester tumor promoters and of capsaicin (see structures in Fig. 1), functions as an ultrapotent capsaicin analog (4—6) and that the esterification of other phorbol-related diterpenes with homovanillic acid at the C-20 position yields synthetic vanilloids of the RTX class with unique spectra of action (7).
They both cause an initial stimulation and inflammation, capsaicin much more so than resiniferatoxin.
In heterologous expression systems, TRPV1 can be activated not only by vanilloid compounds, but also by resiniferatoxin, extracellular protons, and arachidonic acid metabolites.
Use resiniferatoxin when its meaning, tone and grammar fit the full sentence. A synonym is not always a direct replacement.
Resiniferatoxin means (organic chemistry) A naturally occurring ultrapotent capsaicin analogue (having in its pure form a Scoville heat unit measure of 16,000,000,000) that activates the receptor TRPV1 (aka vanilloid receptor 1 or the capsaicin receptor) in a subpopulation of primary afferent sensory neurons involved in nociception..
Common synonyms include RTX.
The opposite depends on the specific sense.
1992, Arpad Szallasi, Peter M. Blumberg, 27: Resiniferatoxin, P. Michael Conn (editor), Neurotoxins, Harcourt Brace Jovanovich (Academic Press), page 368, An exciting recent advance in the vanilloid field has been our discovery that resiniferatoxin (RTX), a naturally occurring diterpene combining structural features of the phorbol ester tumor promoters and of capsaicin (see structures in Fig. 1), functions as an ultrapotent capsaicin analog (4—6) and that the esterification of other phorbol-related diterpenes with homovanillic acid at the C-20 position yields synthetic vanilloids of the RTX class with unique spectra of action (7).
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